have had chemotherapy or major surgery within 28 days of joining the study, or radiotherapy or minor surgery within 7 days of joining it.have a heart condition or other serious medical condition that isn’t controlled with treatment.currently have an infection, including herpes or chickenpox.have severe diarrhoea (runny poo) that can’t be controlled.have neuropathy (tingling or pins and needles in your fingers and toes) that affects how well your fingers and toes work.But you may be able to take part if you have had gemcitabine, capecitabine or 5FU following surgery to try to remove the cancer (adjuvant chemotherapy), as long as it was at least six months ago and you no longer have side effects. The PRIMUS 001 trial is not suitable for you if you have already had chemotherapy for advanced pancreatic cancer, including nab-paclitaxel and oxaliplatin. have not previously had chemotherapy for advanced pancreatic cancer. are well enough to take part – you will have tests to check this.are taking part in the Precision Panc study.The PRIMUS-001 trial may be suitable for you if you: They want to see if differences in the genes affect how well the treatments work. Researchers will use these samples to look at the genetic changes in your cancer. This means that you will need to join the Precision Panc study and provide blood and tissue samples in order to take part in the PRIMUS-001 trial. This trial is part of the Precision Panc study. You can ask the research nurse what the treatment you have been selected for will involve. You and your doctor will know which treatment you are receiving. This is a randomised trial, so people taking part will be randomly selected to have one treatment or the other. Half the people taking part will have FOLFOX and nab-paclitaxel, and half will have gemcitabine and nab-paclitaxel. The PRIMUS-001 trial will compare two different combinations of chemotherapy to see which works better, and which causes more side effects. Surgery isn’t possible if the cancer has spread, but you may be able to have chemotherapy. Pancreatic cancer that has spread to other parts of the body is called advanced or metastatic pancreatic cancer. Research title: PRIMUS-001: An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation Why is this trial being carried out? Con un semplice clic sul pulsante "Disinstalla" all’interno di di Revo Uninstaller Pro puoi usare questi registri per disinstallare dei programmi dal tuo computer.PRIMUS-001: A phase II study comparing FOLFOX and nab-paclitaxel chemotherapies to gemcitabine and nab-paclitaxel for pancreatic cancer that has spread to other parts of the body È un database contenente registri tracciati di programmi installati, conservato sul nostro sito web, preparato e mantenuto dal team di Revo Uninstaller Pro.
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